Highly effective mucolytic therapy in cystic fibrosis and bronchiolitis
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Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines.
BACKGROUND Cough-suppressant therapy, previously termed nonspecific antitussive therapy, incorporates the use of pharmacologic agents with mucolytic effects and/or inhibitory effects on the cough reflex itself. The intent of this type of therapy is to reduce the frequency and/or intensity of coughing on a short-term basis. METHODS Data for this review were obtained from several National Libra...
متن کاملUse of macrolides in lung diseases: recent literature controversies.
OBJECTIVE To review the mechanisms of action of macrolides in pediatric respiratory diseases and their clinical indications. SOURCES Review in the PubMed database, comprising the following terms in English: "macrolide and asthma"; "macrolide and cystic fibrosis"; "macrolide bronchiolitis and viral acute"; "macrolide and bronchiolitis obliterans" and "macrolide and non-CF bronchiectasis". SU...
متن کاملReview: mucolytic drugs reduce exacerbations, illness days, and antibiotic use in chronic bronchitis and COPD.
S t u d y s e l e c t i o n Studies were selected if they were randomized, double-blind, placebo-controlled trials of oral mucolytic drugs taken regularly for ≥ 2 months by adults who were > 20 years of age and had chronic bronchitis or COPD. Studies on inhaled mucolytic drugs, combinations of mucolytic drugs with antibiotics or bronchodilators, deoxyribonucleases, and such proteases as trypsin...
متن کاملIn vitro assessment of combined antibiotic and mucolytic treatment for Pseudomonas aeruginosa infection in cystic fibrosis.
The minimal inhibitory concentration of azlocillin for Pseudomonas aeruginosa is appreciably reduced when combined with the mucolytic agent mesna (Mistabron) because of an independent bacteriostatic effect of mesna. Bactericidal activity of azlocillin is unaltered by mesna. Mesna inhalations alone or combined with azlocillin may benefit cystic fibrosis patients with pseudomonas lung infections.
متن کاملTransplantation of the lung.
The introduction of cyclosporine as a highly effective immunosuppressive agent and the development of new techniques for heart-lung and lung transplantation have led to a new treatment for a wide range of fatal cardiopulmonary diseases. Indications for surgery are now becoming clear, together with major contra-indications. Suppurative lung disease, such as cystic fibrosis, can be effectively tr...
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